Interstate 80 goes straight through the Skylands. It goes east towards Metro New York and west all the way to San Francisco, passing through or near many major cities in the Midwest, the Rocky Mountains and the Southwest of the United States.
In Pennsylvania,
the Poconos just on the other side of the Delaware Water Gap National Recreation Area see above
Wilkes-Barre
Pittsburgh
and beyond:
Toledo, Ohio
Joliet, Illinois near Chicago
Des Moines, Iowa
Cheyenne, Wyoming
Salt Lake City, Utah
Sacramento, California